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The whole world endeavors to end smoking and declares war against cigarettes and tobacco.
The population of smokers in the world exceeded 1.3 billions in 1999, and the deaths from smoking reached around 4 millions per year, which was more deaths than those from alcohol, illegal drugs, violence, traffic accidents or AIDS.
According to a report from the WHO, it is estimated that the deaths from smoking will reach 10 million by 2030, and of which 70% will occur in Asian countries. The numbers show that one out of ten adults dies form smoking. The numbers show that currently one out of ten adults dies form smoking. It is also predicted in 2030 that one out of six adult will die from smoking.
What is the status of smoking in Korea?
The cigarette smoking population in South Korea was approximately 12.4 million in 1999, and that is about 23% of the adult population. This also means that one fourth of the people smoke cigarettes over 20 years.  Surprisingly, the smoking percentage of 3rd grade students in the high school is 41.6% that may be the highest in the world.
Recently, the number of female smokers at the childbearing age in their 20's to 30's is sharply increasing.
Is there a reason the population of smokers is not being reduced, while health authorities of the entire world carry on the campaign wars against smoking?
Smoking is usually started by curiosity and it makes smokers addicted to the substances in cigarettes. Then they smoke more frequently, and finally are unable to quit smoking due to habituation.
It is reported to academia that the smoke of cigarettes contain approximately 4,000 chemical substances, that can be roughly divided into tar, nicotine and gaseous components.
Tar is dark brown thick liquid that is concentrated from minute particles that can be seen on white paper when you inhale the cigarette smoke into your mouth and blow it out.

There are 16 or more types of carcinogens and toxic substances in the tar.  A small amount of the tar can kill animals that weight less than 3kg and most of the insects. The tar in humans causes disease, cancer,  bronchitis, emphysema, asthma, stomach ulcers, heart disease, hypertension, oral cancer, pharynx cancer, esophageal cancer, laryngeal cancer, pancreatic cancer, kidney cancer, urinary bladder cancer, and so forth.
If one smokes a pack of cigarette each day, a glass full of tar could be collected in a year.
Nicotine performs various pharmacological effects in the body such as the constriction of capillary and peripheral vessels. It raises blood pressure, exasperates the heartbeat, stimulates the nerves, damages blood vessel walls, and accelerates arteriosclerosis.  More than anything else, nicotine develops the habituation to keep on smoking.
Around 2mg of nicotine is in a cigarette, and the amount of nicotine in two packs (40 sticks) of cigarettes can kill a human being if taken simultaneously.
The most hazardous gas emitted by cigarettes is carbon monoxide (CO).  Smoking provokes chronic hypoxia like smelling continuously a bit anthracite coal, disturbs metabolism, and causes senile changes that make it difficult to maintain a sound mentality.
Consequently the damage from cigarettes threatens smoker’s life.
According to a number of epidemiological studies publicized by the health authority and medical circles, smokers generally live shorter than non-smokers by five to eight years.
If a 25 year old man smokes a pack of cigarettes daily, his life expectancy would be 4.6 years less than a non-smoker, and 8.3 years would less if he smokes two packs of cigarettes every day.

A smoker's life span will be reduced by 5 minutes and 30 seconds by smoking a cigarette when compared to the average life expectancy.
Indirect smoking by nonsmokers is at a serious level as well.
85% of the smoke that nonsmokers inhale is that of side-stream smoke coming from the tip of a cigarette. It contains two to three times higher toxic substances levels and carcinogens than the remaining 15% of main-stream smoke that smokers exhale.

Furthermore, the research team from Shizuoka Prefecture Infant Hospital in Japan found that one seventh of the total smoke inhaled by pregnant women is transferred to her unborn baby.  The test was done though a urinalysis of newly born babies before initial nursing within 24 hours from the birth. Indirect smoking can give babies a fatal respiratory problem, hinder their growth, and so on.
As WHO pointed out at the international conference in 1999, babies of smoking mothers make up 1/3 to half of S.I.D.S. (sudden infant death syndrome) deaths because of damage from indirect smoking.
If one of the parents smokes, the children’s probability of being attacked by bronchitis or pneumonia is 1.7 times more than non-smoking parent. Then if both parents smoke, the probability would be increased by 2.6 times, and symptoms of chronic coughing or sputum is 30% to 80% higher than non-smoking parent group.
In addition, indirect smoking raises the rates of other diseases such as paranasal sinuses cancer, brain cancer and etc.

How can the damage from cigarettes be fixed?
Everyone first points out that one should refrain from smoking.
Various supplements, remedies, have been developed to help smokers stop smoking are sold at market.  However most of them are neglected because they are less effective than expected, are difficult to use, or have unexpected side effects. Under these circumstances, NPL-X (Brand: NOSMO), stop smoking product of made from a medicinal herb, has been developed by our own technology in Korea that has  caught the eyes of medical, pharmaceutical circles, smokers who want to quit smoking, and journalists.
All of the interests are focused on ‘NPL-X’ the core substance and its stop smoking mechanism.

<Comment of Mr. Sun Ho Park – CEO>
CEO Sun Ho Park, NOSMO Co., Ltd.
PDR is the source of prescription information approved by FDA that is the most reliable in the United States, which medical experts consult innumerably.
Besides that, the product got HT Certification from the Korean Ministry for Health, Welfare and Family Affairs approves it as a new health technology, and has been honorably appointed it as a Priority Purchase Product by the Korean Intellectual Property Office.
<Mr. Park’s Comment>
NOSMO acquired HT Certificate and the Korean Ministry for Health, Welfare and Family acknowledges it as a new health technology. It has been chosen as a Priority Purchase Product by the Commissioner of Korean Intellectual Property Office.
Professor Ho Jae Lee announced that ‘NPL-X’, the core substance of the stop-smoking product was registered as a ‘New Dietary Ingredient’ and the applicable material that can be used for a dietary supplement in accordance with code 413a of US FD&C (United States Federal Food, Drug and Cosmetic Act) through the strict inspection of the FDA.
He is a professor led the research team of Food Science Division of Dong Eui Institute of Technology in Busan, Korea.
FDA Dietary Supplement ³ë½º¸ð New Dietary Ingredient
NOSMO was registered at New Dietary Ingredient of FDA Dietary Supplement as the applicable material
The technology has been developed by the industry-university cooperation between Dr. Lee and NOSMO Co., Ltd. (CEO: Sun Ho Park – www.nosmo.co.kr). It was successfully commercialized, introduced later in the US, and Japan in the form of tea, tablets and candy.
Dr. Lee, the developer of the technology has researched mainly functional natural colors, oxycatotenoids, traditional medicinal herbs and so forth in the field of nutraceuticals. Using traditional medicinal herbs, he has developed the products to stop smoking for ten years now.
The motive of Dr. Lee’s development of the stop-smoking product is unexpectedly pure.

<Dr. Lee’s Comment>
I noticed that lots of smokers could not quit smoking even when they were in very bad physical condition and well aware of the harmfulness of cigarette smoking.  I started to develop anti-smoking products based on my thought that it would be a rewarding job as a scientist to study to help them.
Professor Ho Jae Lee, Food Science Division, Dong Eui Institute of Technology
There are lots of stop-smoking aid products, however, the effective ones are rarely   found.  At the moment, there are roughly two groups of stop-smoking products that are on the market.
One group is analogous smoking functional products, and the other group of products infuses nicotine into the smoker’s body.
Finally Dr. Lee found the solution to be a secret method of the traditional medicinal herbs that suits our physical constitutions.
At first I selected the medicinal herbs that protect the smoking directly related internal organs such as bronchus and cardiopulmonary function among numerous medicinal herbs listed in ‘Dong Eui Bo Gam”. This book is the most authentic and comprehensive bibliography on Korean traditional medicinal herbs since a few centuries ago.
And I investigated the anti-oxidization functions of the selected medicinal herbs. The primary material that damages smokers is ‘reactive oxygen species’ (harmful oxygen that induces aging and diseases) created by smoking. In this connection, I selected first highly effective medicinal herbs to eliminate the active oxygen.  Among those selected potentials, I repeatedly selected the medicinal herbs that possess the most effective functions to break down and discharge nicotine.  The development of NPL-X was completed by finally selecting medicinal herbs.
The reason Dr. Lee researched the process to find new substances was that the primary physiological damage of smoking to smokers is caused by the reactive oxygen species created by smoking cigarette.
The next consideration of Dr. Lee’s research was a way of reducing withdrawal symptoms that is the most difficult obstacle to quit smoking.  Dr. Lee settled the issue by the concept of ‘Time and Concentration’.

<Dr. Lee’s Comment>
When a smoker attempts to quit smoking, sensitivity of nicotine receptors causes withdrawal symptoms and these symptoms increase gradually by reducing the concentration of nicotine. In a certain event, the number of the nicotine receptors itself is increased, therefore the smoker can’t quit smoking and falls again into nicotine addiction. We worked out a strategy to overcome the withdrawal symptoms by discharging nicotine rapidly out of the body, since it takes time more or less time for the receptors to respond to the decrease of nicotine concentrations.
Consequently Dr. Lee has proceeded to promote the discharging action of nicotine in order to promptly exhaust the degraded nicotine out of body by formulating medicinal herbs from the initially selected ones.
Dr. Lee said that the conception of discharging nicotine out of body was opposite to the conventional stop-smoking supplement products that induce nicotine into the body, and his research plan seemed to be an unreasonable and impossible one.
But Dr. Lee’s hypothesis was scientifically proven by the remarkable results of the clinical trials on smokers.
We have performed the clinical trials on 100 smokers in Korea and abroad to prove the effect of our product. Through the trials, around 40% of smokers successfully quit smoking, and amazingly they did not feel any side effects at all.  We got the remarkable result of approximately 65% of smokers to successfully quit smoking at the clinical trial in Italy.
65% successfully quit smoking in two weeks
Dr. Lee declared that his team established the On/Off theory of withdrawal symptoms of nicotine concentration through the experiment and could identify the principle that NPL-X(Brand: NOSMO) uses to restrain withdrawal of symptoms.
The concentration of nicotine in a smoker’s body is rapidly decreased when he stops smoking, but small amount of nicotine is not easily discharged from human body and remains for a long period of time. Nicotine receptors in the body send signals toward the brain to recover the original nicotine concentration in the body. This phenomenon  is called the withdrawal symptom.  Then the smoker suffers from the pain from quitting smoking.  Accordingly, the key to successfully quit smoking is how fast the smoker can get out of the area of the concentration. Our product enables smokers to be successful when quitting smoking by exhausting nicotine rapidly, reducing the concentration of nicotine and relieving of the area of concentration sounds weird quickly.
It can be compared to electrodes; the phenomenon looks like electric sparks between two close electrodes. However, when the electrodes don't spark when they are further apart.
Dr. Lee’s result in the experiment and hypothesis has been registered with 2 patents and the international patent was filed in 32 countries including the United States, Japan, China and EU countries. The function and effect were reported by numerous news papers in Korea and foreign countries.
He expected that the registration of the raw substance and NDC would be a good opportunity to advertise the excellence of Korean technology in the field of heath industry throughout the world, enhance the sale and profit of the company by exporting the products utilizing the technology. 
In the meantime, Dr. Lee has done follow-up research plans to identify the chemical structure of the core substance of NPL-X, which exhibited the functions to restrain withdrawal symptoms.
I have a plan to research the mechanism of addiction and withdrawal symptoms in order to resolve the issues of drugs and alcohol addiction that have the similar mechanisms like the addiction of nicotine. 


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